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  * Chagas' Disease
    [American Trypanosomiasis]
  * African Sleeping Sickness
    [African Trypanosomiasis]
  * Leishmaniasis
  * Malaria
Target Organisms
  * Trypanosoma cruzi
  * Trypanosoma brucei
  * Leishmania spp.
  * Plasmodium falciparum
  * (Plasmodium vivax)
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MALARIA
Malaria (Plasmodium falciparum)

Malaria (Plasmodium falciparum) has the potential to infect more than 40% of the world's population! One-hundred countries are reported with endemic transmission. The annual incidence ranges from 300 to 500 million; and, this high morbidity proves to be a drain on economics. Current World Health Organization (WHO) estimates report 1.5-2.7 million deaths from malaria per year. Most of the victums are young (less than five years old) African children. Vaccines are highly unlikely due to antigenic variation and the parasite's resistance to drugs has proved to be a huge problem.

Organism Plasmodium falciparum
At Risk More than 40% of world population
(see map below)
Humans Infected 300-500 million
Disease Outcome Often fatal in children and pregnant women
Vaccine Prospects Poor due to antigenic variation
Available Drugs Chloroquine, Quinine/doxycycline, Mefloquine,
Pyrimethamine/Sulfadoxine,
Atovaquone/Proguanil, Artemether
Drug Resistance Documented

General Information: Medline, World Health Organization