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| Project Description |
| Flow Diagrams |
| Contact Information |
| Consortium Members |
| Diseases Under Investigation |
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* Chagas' Disease [American Trypanosomiasis] |
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* African Sleeping Sickness [African Trypanosomiasis] |
| * Leishmaniasis |
| * Malaria |
| Target Organisms |
| * Trypanosoma cruzi |
| * Trypanosoma brucei |
| * Leishmania spp. |
| * Plasmodium falciparum |
| * (Plasmodium vivax) |
| Genome Status |
| SGPP Progress |
| Papers by SGPP |
| Related Links/Resources |
| Employment Opportunities |
| SGPP News Articles |
| Feedback on SGPP web site |
|
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SGPP PAPERS
"Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor"
Jürgen Bosch, Stewart Turley, Thomas M. Daly, Stephen M. Bogh, Michelle L. Villasmil, Claudia Roach, Na Zhou, Joanne M. Morrisey, Akhil B. Vaidya, Lawrence W. Bergman and Wim G. J. Hol.
Proceedings of the National Academy of Sciences,
Epub 2006 Mar 17 10.1073/pnas.0510907103; print 2006 Mar 28;103(13):4852-4857
"Heterologous expression of proteins from Plasmodium falciparum: Results from 1000 genes",
Christopher Mehlin, Erica Boni, Frederick S Buckner, Linnea Engel, Tiffany Feist,
Michael H Gelb, Lutfiyah Haji, David Kim, Colleen Liu, Natascha Mueller, Peter J Myler,
J T Reddy, Joshua N Sampson, E Subramanian, Wesley C Van Voorhis, Elizabeth Worthey,
Frank Zucker, Wim G J Hol.
Mol Biochem Parasitol
Epub 2006 Apr 18 doi:10.1016/j.molbiopara.2006.03.011; print 2006 Aug 1;148(2):144-160
"The structure of Plasmodium vivax phosphatidylethanolamine-binding protein
suggests a functional motif containing a left-handed helix",
T. Arakaki, H. Neely, E. Boni, N. Mueller, F. S. Buckner, W. C. Van Voorhis, A.
Lauricella, G. DeTitta, J. Luft, W. G. J. Hol and E. A. Merritt.
Acta Cryst.
2007 F63, 178-182, doi:10.1107/S1744309107007580
"Structure of ribose 5-phosphate isomerase from Plasmodium falciparum",
Margaret A. Holmes, Frederick S. Buckner, Wesley C. Van Voorhis, Christophe L.
M. J. Verlinde, Christopher Mehlin, Erica Boni, George DeTitta, Joseph Luft,
Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Frank Zucker, Lori W.
Schoenfeld, Thomas N. Earnest, Wim G. J. Hol and Ethan A. Merritt.
Acta Cryst. (2006 May) F62, 427-431
(Copyright © International Union of Crystallography)
"Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major",
Tracy Arakaki, Isolde Le Trong, Eric Phizicky, Erin Quartley, George DeTitta, Joseph Luft, Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Elizabeth Worthey, Peter J. Myler, David Kim, David Baker, Wim G.J. Hol and Ethan A. Merritt.
Acta Cryst. (2006 March) F62, 175-179.
(Copyright © International Union of Crystallography)
"Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum",
Margaret A. Holmes, Frederick S. Buckner, Wesley C.E. Van Voorhis, Christopher Mehlin, Erica Boni, Thomas N. Earnest, George DeTitta, Joseph Luft, Angela Lauricella, Lori Anderson, Oleksandr Kalyuzhniy, Frank Zucker, Lori W. Schoenfeld, Wim G.J. Hol and Ethan A. Merritt.
Acta Cryst. (2006 March) F62, 180-185.
(Copyright © International Union of Crystallography) "Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum", J. Caruthers, J. Bosch, F. Buckner, W. Van Voorhis, P. Myler, E. Worthey, C. Mehlin, E. Boni, G. DeTitta, J. Luft, A. Lauricella, O. Kalyuzhniy, L. Anderson, F. Zucker, M. Soltis, Wim G. J. Hol. PROTEINS: Structure, Function, and Bioinformatics 2006 Feb 1;62(2):338-342 [You can download the paper here.] "Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25Å Resolution reveals intriguing extra electron density in the active site", Mark A. Robien, Jürgen Bosch, Frederick S. Buckner, Wesley C.E. Van Voorhis, Elizabeth A. Worthey, Peter Myler, Christopher Mehlin, Erica E Boni, Oleksandr Kalyuzhniy, Lori Anderson, Angela Lauricella, Stacy Gulde, Joseph R. Luft, George DeTitta, Jonathan M. Caruthers, Keith O. Hodgson, Michael Soltis, Frank Zucker, Christophe L.M.J. Verlinde, Ethan A. Merritt, Lori W. Schoenfeld and Wim G.J. Hol. PROTEINS: Structure, Function, and Bioinformatics, Epub 2005 Dec 12; print 2006 62: 570-577
"Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily",
Jonathan Caruthers, Frank Zucker, Elizabeth Worthey, Peter J Myler, Fred Buckner, Wes Van Voorhuis, Chris Mehlin, Erica Boni, Tiffany Feist, Joseph Luft, Stacey Gulde, Angela Lauricella, Oleksandr Kaluzhniy, Lori Anderson, Isolde Le Trong, Margaret A Holmes, Thomas Earnest, Michael Soltis, Keith O Hodgson, Wim G J Hol and Ethan A Merritt.
Protein Science Epub 2005 Sep 30; print 2005 Nov, 14(11):2887-2894
"Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine",
Claudia Schnick, Mark A. Robien, Andrzej M. Brzozowski, Eleanor J. Dodson, Garib N. Murshudov, Lori Anderson, Joseph R. Luft, Chris Mehlin, Wim G. J. Hol, James A. Brannigan and Anthony J. Wilkinson.
Acta Cryst Section D. 2005 Sep;61(Pt 9):1245-1254. Epub 2005 Aug 16.
"Automated Prediction of Domain Boundaries in CASP6 Targets Using Ginzu and RosettaDOM",
Kim, D.E., Chivian, D., Malmstrom, L., and Baker, D.
Proteins 2005 Sep 26; [Epub ahead of print]
"Prediction of CASP-6 structures using automated Robetta protocols",
Chivian, D., Kim, D.E., Malmstrom, L., Rohl, C.A., Schonbrun, J., and Baker, D.
Proteins 2005 Sep 26; [Epub ahead of print]
"Rapid Isolation of Antibodies for Structural Genomics",
Shea, C., Bloedorn, L. and Sullivan, MA.
Journal of Structural and Functional Genomics 2005;6(2-3):171-175.
"A Protein Interaction Network of the Malaria Parasite Plasmodium falciparum",
Douglas LaCount, Marissa Vignali, Rakesh Chettier, Amit Phansalkar, Russell Bell, Jay Hesselberth, Lori Schoenfeld, Irene Ota, Sudhir Sahasrabuhde, Cornelia Kurschner, Stanley Fields and Robert Hughes.
Nature 2005 Nov 3;438(7064):103-107.
"Structure-Based Drug Discovery for Plasmodium falciparum",
Christopher Mehlin.
Combinatorial Chemistry & High Throughput Screening 2005, 8, 5-14.
"Protein structure prediction and analysis using the Robetta server",
David E. Kim, Dylan Chivian and David Baker.
Nucleic Acids Research 2004 Jul 1;32(Web Server issue):W526-531. DOI: 10.1093/nar/gkh468
"Automated affinity chromatography measurements of compound mixtures using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry",
Yuko Ogata, Louis Scampavia, Tyan L. Carter,a Erkang Fan, and Frantinek Turebeka.
Analytical Biochemistry 2004 Aug 1;331(1):161-168.
"Cloning grills: High throughput cloning for structural genomics",
Christopher Mehlin1, Erica E. Boni, Jamie Andreyka and Richard W. Terry.
Journal of Structural and Functional Genomics 2004;5(1-2):59-61.
"Solid-phase synthesis of 1,5-substituted 2-(N-alkylamino)-imidazolidin-4-ones",
Jizhen Li, Zhenfa Zhang and Erkang Fan.
Tetrahedron Letters Volume 45, Issue 6, 2 February 2004, Pages 1267-1269.
"A Facile Method for High-throughput Co-expression of Protein Pairs",
Andrei Alexandrov, Marissa Vignali, Douglas J. LaCount, Erin Quartley, Christina de Vries, Daniela De Rosa, Julie Babulski, Sarah F. Mitchell, Lori W. Schoenfeld, Stanley Fields, Wim G. Hol, Mark E. Dumont, Eric M. Phizicky, and Elizabeth J. Grayhack.
Molecular & Cellular Proteomics 2004 Sep;3(9):934-8. Epub 2004 Jul 7.
"mmLib Python toolkit for manipulating annotated structural models of biological macromolecules",
Jay Painter and Ethan A Merritt.
Journal of Applied Crystallography (2004). 37, 174-178 [doi:10.1107/S0021889803025639] ISSN 0021-8898.
"An improved protocol for rapid freezing of protein samples for long-term storage",
Junpeng Deng, Douglas R. Davies, Goragot Wisedchaisri, Meiting Wu, Wim G. J. Hol and Christopher Mehlin.
Biological Crystallography 2004 Jan;60(Pt 1):203-204. Epub 2003 Dec 18. ISSN 0907-4449.
"A deliberate approach to screening for initial crystallization conditions of biological macromolecules",
Joseph R. Luft, Robert J. Collins, Nancy A. Fehrman, Angela M. Lauricella, Christina K. Veatch, and George T. DeTitta.
Journal of Structural Biology 2003 Apr;142(1):170-179.
"TFA-Sensitive Arylsulfonylthiourea-Assisted Synthesis of N,N¢-Substituted Guanidines",
Jizhen Li, Guangtao Zhang, Zhongsheng Zhang, and Erkang Fan.
J. Org. Chem. 2003; 68(4); 1611-1614. DOI: 10.1021/jo026807m |
