SGPP | 3-D Structures

Plasmodium falciparum
	Pfal008434AAA Plasmodium falciparum ribose 5-phosphate isomerase [ PDB-ID 2F8M ]
	Pfal000304AAA Plasmodium falciparum (orotidine-5'-monophosphate decarboxylase) to 2.1Å resolution
	Pfal004331AAA Plasmodium falciparum hypothetical protein [ PDB-ID 1ZSO ]
	Pfal007254AAA Plasmodium falciparum Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme. This target has been an exploratory target for drug design by the MMV (Medicines for Malaria Venture: http://www.mmv.org). Shown in CPK format are 4 copies of the NAD cofactor found in the 2.25 Angstrom homotetrameric crystal structure.
	Pfal009167AAA D-Ribulose 5-Phosphate 3-Epimerase Enzyme from the oxidative pentose phosphate pathway (critical for the generation of NADPH) [ PDB-ID 1TQX ]
	Pfal008421AAA Plasmodium falciparum Homolog Of Uridine Phosphorylase/Purine Nucleoside Phosphorylase [ PDB-ID 1SQ6 ]
	Pfal009132AAA NAD-dependent Glycerol-3-Phosphate Dehyrogenase from Plasmodium falciparum [ PDB-ID 1YJ8 ]
	Pfal007201AAA Plasmodium falciparum Thioredoxin [ PDB-ID 1SYR ]
	Pfal006645AAA Plasmodium falciparum nucleoside diphosphate kinase B [ PDB-ID 1XIQ ]
	Pfal004546AAA Plasmodium falciparum 6-pyruvoyl tetrahydrobiopterin synthase (PTPS) [ PDB-ID 1Y13 ]
	Pfal005984AAA Phosphoglycerate mutase Metabolic enzyme; potential antimalarial drug target [ PDB-ID 1XQ9 ]
Plasmodium knowlesi
	Pkno008421AAA Plasmodium knowlesi Purine nucleoside phosphorylase - a homolog of Pfal008421AAA.
Plasmodium berghei
	Pber005319AAA Plasmodium berghei superoxide dismutase [ PDB-ID 2A03 ]
Plasmodium vivax
	Pviv002324AAA Plasmodium vivax hypothetical protein Homolog to proteins belonging to the Haloacid Dehydrogenase superfamily, subfamily IIB [ PDB-ID 2B30 ]
Leishmania major
	Lmaj006873AAA Leishmania major hypothetical protein [ PDB-ID 2B4W ]
	Lmaj005461AAB [ PDB-ID 1YF9 ]
	Lmaj011689AAA The resolution is 2.3A [ PDB-ID 1YQF ]
	Lmaj008024AAA Leishmania major Homology of low-speceficity Threonine Aldolase [ PDB-ID 1SVV ]
	Lmaj01134AAC This N-terminally truncated protein is a Leishmania major (Friedlin) homolog of the "programmed cell death 6" protein [ PDB-ID 1Y1X ]
	Lmaj001686AAA Putative mitochondrial associated ribonuclease (90% sequence identity to Leishmania tarentolae MAR1) high structural homology to N-carbamoylsarcosine amidohydrolase (15% sequence identity) including active site Cys [ PDB-ID 1XN4 ]
	Lmaj002144AAA Leishmania major hypothetical protein [ PDB-ID 1R75 ]
	Lmaj004091AAA SAM dependent Methyltransferase (similar to ubiquinone MT) [ PDB-ID 1XTP ]
	Lmaj004144AAA Leishmania major, probable kinase (? nuclear adenylate kinase) [ PDB-ID 1Y63 ]
	Lmaj005534AAA Eukaryotic D-Amino Acid tRNA Deacylase [ PDB-ID 1TC5 ]
	Lmaj006238AAA Eukaryotic initiation factor 2B [ PDB-ID 2A0U ]
	Lmaj006828AAA Identified by structural homology to be oxygen dependent coproporphyrinogen oxidase (CPO) an essential enzyme in the heme biosynthetic pathway [ PDB-ID 1VJU ]
Leishmania donovani
	Ldon001686AAA Putative mitochondrial associated ribonuclease (90% sequence identity to L. tarentolae MAR1) high structural homology to N-carbamoylsarcosine amidohydrolase (15% sequence identity) including active site Cys [ PDB-ID 1X9G ]
Leishmania mexicana
	Lmex003024AAA Eukaryotic initiation factor 5A from Leishmania mexicana [ PDB-ID 1XTD ]
Leishmania braziliensis
	Lbra003024AAA Eukaryotic initiation factor 5A from Leishmania braziliensis [ PDB-ID 1X6O ]
Trypanosoma brucei
	Tbru015978AAA Dihydroorotate dehydrogenase from Trypanosoma brucei [ PDB-ID 2B4G ]
	Tbru015777AAA [ PDB-ID 2A0K ]
Trypanosoma cruzi
	Tcru010945AAA Arginase superfamily protein from Trypanosoma cruzi. [ PDB-ID 2A0M ]
	Tcru003547AAA Native structure Tcru003547 ribbon diagram showing bound sulfate and large unknown ligand courtesy of E coli (mFo-Fc density at 4 and 7 sigma) [ PDB-ID 1YZV ]
	Tcru013382AAA Native structure Cyclophilin (Cyclosporin-A binding protein) Potential drug target PDB 1XQ7 Cyclophilin complexed with known anti-Leishmanial agent Cyclosporin [ PDB-ID 1XO7 ]
	Tcru0013382AAA Bound to cyclosporin [ PDB-ID 1XQ7 ]
Super folder
	DBsf000001AYE Engineered protein designed to mimic fold of 1AYE [ PDB-ID 1VJQ ]

Additional Pathogenic Protozoan Structures Solved by SGPP Members

Plasmodium falciparum
	Fructose-1,6-bisphosphate Aldolase Crystal structure of fructose-1,6-bisphosphate aldolase from the human malaria parasite Plasmodium falciparum. [ PDB-ID 1A5C ] Kim, H., Certa, U., Dobeli, H., Jakob, P., Hol, W. G. Biochemistry 1998 37:4388 [ Medline ]
	Peptide Deformylase Crystals of Peptide Deformylase from Plasmodium falciparum Reveal Critical Characteristics of the Active Site for Drug Design. [ PDB-ID 1JYM ] Abhinav Kumar, Kiet T. Nguyen, Sumant Srivathsan, Brad Ornstein, Stewart Turley, Irwin Hirsh, Dehua Pei and Wim G. J. Hol Structure 2002 357-367 [ Article ]
Leishmania mexicana
	Glyceraldehyde 3-Phosphate Dehydrogenase Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. [ PDB-ID 1GYP ] Kim, H., Feil, I. K., Verlinde, C. L., Petra, P. H., Hol, W. G. Biochemistry 1995 34:14975 [ Medline ]
	Glycerol-3-phosphate Dehydrogenase A Potential Target Enzyme for Trypanocidal Drugs Revealed by the Crystal Structure of Nad-Dependent Glycerol-3-Phosphate Dehydrogenase from Leishmania Mexicana. [ PDB-ID 1EVY ] Suresh, S., Turley, S., Opperdoes, F. R., Michels, P. A. M., Hol, W. G. J. Structure 2000 8:541 [ Medline ]
	Fructose-1,6-bisphosphate Aldolase Structures of Type 2 Peroxisomal Targeting Signals in Two Trypansomatid Aldolases. [ PDB-ID 1EPX ] Chudzik, D. M., Michels, P. A., De Walque, S., Hol, W. G. J. J.Mol.Biol. 2000 300:697 [ Medline ]
Trypanosoma brucei
	Triosephosphate Isomerase Structure Determination of the Glycosomal Triosphosphate Isomerase from Trypanosoma brucei at 2.4 Angstrom Resolution. [ PDB-ID 5TIM ] Rik K. Wierenga, Kor H. Kalk and Wim G. J. Hol Journal of Molecular Biology 1987 198:109-121
	Glyceraldehyde-3-phosphate Dehydrogenase Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data. [ PDB-ID 1GGA ] Vellieux, F. M., Hajdu, J., Verlinde, C. L., Groendijk, H., Read, R. J., Greenhough, T. J., Campbell, J. W., Kalk, K. H., Littlechild, J. A., Watson, H. C., , et al. Proc Natl Acad Sci USA 1993 90:2355 [ Medline ]
	Phosphoglycerate Kinase A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. [ PDB-ID 16PK ] Bernstein, B. E., Williams, D. M., Bressi, J. C., Kuhn, P., Gelb, M. H., Blackburn, G. M., Hol, W. G. J Mol Biol 1998 279:1137 [ Medline ]
	Fructose-1,6-bisphosphate Aldolase Structures of Type 2 Peroxisomal Targeting Signals in Two Trypansomatid Aldolases. [ PDB-ID 1F2J ] Chudzik, D. M., Michels, P. A., De Walque, S., Hol, W. G. J. J.Mol.Biol. 2000 300:697 [ Medline ]
	Peroxin 5 Fragment An Unexpected Extended Conformation for the Third Tpr Motif of the Peroxin Pex5 from Trypanosoma Brucei. [ PDB-ID 1HXI ] Kumar, A., Roach, C., Hirsh, I. S., Turley, S., Dewalque, S., Michels, P. A. M., Hol, W. G. J. J.Mol.Biol. 2001 307:271 [ Medline ]